Many schools and other UN facilities have been used as shelters by the 1.7 million people who have fled their homes during the war, which has lasted almost eight months.
A previous attack in June on another packed UN-run school in Nuseirat killed at least 35 people.
Local journalists told the BBC at the time that a warplane fired two missiles at classrooms on the top floor of the school.
After that attack, Israel’s military said it had “conducted a precise strike on a Hamas compound” in the school and killed many of the 20 to 30 fighters it believed were inside.
Gaza’s Hamas-run Government Media Office denied the claim and accused Israel of carrying out a “horrific massacre”.
The head of the UN agency for Palestinian refugees (Unrwa), which runs the school, described the June incident as “horrific” and said the claim that armed groups might have been inside a shelter was “shocking” but could not be confirmed.
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